ParkinsonCanadaV1, Main, Exploration, bibRecord, 002919

LRRK2 expression in normal and pathologic human brain and in human cell lines

Identifieur interne : 002919 ( Main/Exploration ); précédent : 002918; suivant : 002920

LRRK2 expression in normal and pathologic human brain and in human cell lines

Auteurs : Judith Miklossy [Canada] ; Tetsuaki Arai [Japon] ; Jian-Ping Guo [Canada] ; Andis Klegeris [Canada] ; SHENG YU [Canada] ; Edith G. Mcgeer [Canada] ; Patrick L. Mcgeer [Canada]

Source :

Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2006.

RBID : Pascal:06-0496840

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Démence Alzheimer, Sclérose latérale amyotrophique, Chorée Huntington, Parkinson maladie, Parkinson démence ile de Guam, Démence Pick, Homme, Lignée cellulaire, Corps Lewy, Corps Lewy maladie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer disease, Amyotrophic lateral sclerosis, Astrocytes (metabolism), Biomarkers (analysis), Blotting, Western, Brain (metabolism), Brain (pathology), Cell line, Cells, Cultured, Female, Guam Parkinson dementia, Human, Humans, Huntington disease, Immunohistochemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Lewy body, Lewy body disease, Liver (metabolism), Male, Microglia (metabolism), Middle Aged, Myocardium (metabolism), Nervous system diseases, Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (pathology), Oligodendroglia (metabolism), Parkinson disease, Pick disease, Protein-Serine-Threonine Kinases (biosynthesis), RNA, Messenger (analysis), Reverse Transcriptase Polymerase Chain Reaction.
MESH :
- chemical , analysis : Biomarkers, RNA, Messenger.
- chemical , biosynthesis : Protein-Serine-Threonine Kinases.
- metabolism : Astrocytes, Brain, Liver, Microglia, Myocardium, Neurodegenerative Diseases, Oligodendroglia.
- pathology : Brain, Neurodegenerative Diseases.
- Adult, Aged, Aged, 80 and over, Blotting, Western, Cells, Cultured, Female, Humans, Immunohistochemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal-dominant late-onset Parkinson disease. We report that by reverse transcriptase-polymerase chain reaction, the mRNA of LRRK2 is expressed in soluble extracts of human brain, liver, and heart and in cultured human astrocytes, microglia, and oligodendroglia as well as in human neuroblastoma cell lines. We find by Western blotting using a polyclonal antibody of the leucine-rich repeat kinase 2 protein (Lrrk2) specific for C-terminal residues 2511-2527 that an apparent full-length protein and several of its fractions are expressed in soluble extracts of normal human brain. By immunocytochemistry, the antibody recognizes neurons, and more weakly astrocytes and microglia, in normal brain tissue. It intensely labels Lewy bodies in Parkinson disease and related neurodegenerative disorders. It also labels a subset of neurofibrillary tangles in Alzheimer disease and the Parkinsonism dementia complex of Guam (PDCG). It labels thorn-shaped astrocytes and oligodendroglial coiled bodies in PDCG; oligodendroglial inclusions in multiple system atrophy; Pick bodies in Pick disease; nuclear and cytoplasmic inclusions in Huntington disease; and intraneuronal and glial inclusions in amyotrophic lateral sclerosis. In summary, LRRK2 is constitutively expressed in neurons and also in glial cells of human brain. It strongly associates with pathological inclusions in several neurodegenerative disorders.

Affiliations:

Canada, Japon
Tokyo

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer disease</term>
<term>Amyotrophic lateral sclerosis</term>
<term>Astrocytes (metabolism)</term>
<term>Biomarkers (analysis)</term>
<term>Blotting, Western</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Cell line</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Guam Parkinson dementia</term>
<term>Human</term>
<term>Humans</term>
<term>Huntington disease</term>
<term>Immunohistochemistry</term>
<term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term>
<term>Lewy body</term>
<term>Lewy body disease</term>
<term>Liver (metabolism)</term>
<term>Male</term>
<term>Microglia (metabolism)</term>
<term>Middle Aged</term>
<term>Myocardium (metabolism)</term>
<term>Nervous system diseases</term>
<term>Neurodegenerative Diseases (metabolism)</term>
<term>Neurodegenerative Diseases (pathology)</term>
<term>Oligodendroglia (metabolism)</term>
<term>Parkinson disease</term>
<term>Pick disease</term>
<term>Protein-Serine-Threonine Kinases (biosynthesis)</term>
<term>RNA, Messenger (analysis)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Microglia</term>
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<term>Neurodegenerative Diseases</term>
<term>Oligodendroglia</term>
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<term>Neurodegenerative Diseases</term>
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<term>Aged, 80 and over</term>
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<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term>
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<term>Middle Aged</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Démence Alzheimer</term>
<term>Sclérose latérale amyotrophique</term>
<term>Chorée Huntington</term>
<term>Parkinson maladie</term>
<term>Parkinson démence ile de Guam</term>
<term>Démence Pick</term>
<term>Homme</term>
<term>Lignée cellulaire</term>
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<front><div type="abstract" xml:lang="en">Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal-dominant late-onset Parkinson disease. We report that by reverse transcriptase-polymerase chain reaction, the mRNA of LRRK2 is expressed in soluble extracts of human brain, liver, and heart and in cultured human astrocytes, microglia, and oligodendroglia as well as in human neuroblastoma cell lines. We find by Western blotting using a polyclonal antibody of the leucine-rich repeat kinase 2 protein (Lrrk2) specific for C-terminal residues 2511-2527 that an apparent full-length protein and several of its fractions are expressed in soluble extracts of normal human brain. By immunocytochemistry, the antibody recognizes neurons, and more weakly astrocytes and microglia, in normal brain tissue. It intensely labels Lewy bodies in Parkinson disease and related neurodegenerative disorders. It also labels a subset of neurofibrillary tangles in Alzheimer disease and the Parkinsonism dementia complex of Guam (PDCG). It labels thorn-shaped astrocytes and oligodendroglial coiled bodies in PDCG; oligodendroglial inclusions in multiple system atrophy; Pick bodies in Pick disease; nuclear and cytoplasmic inclusions in Huntington disease; and intraneuronal and glial inclusions in amyotrophic lateral sclerosis. In summary, LRRK2 is constitutively expressed in neurons and also in glial cells of human brain. It strongly associates with pathological inclusions in several neurodegenerative disorders.</div>
</front>
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<name sortKey="Sheng Yu" sort="Sheng Yu" uniqKey="Sheng Yu" last="Sheng Yu">SHENG YU</name>
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<country name="Japon"><noRegion><name sortKey="Arai, Tetsuaki" sort="Arai, Tetsuaki" uniqKey="Arai T" first="Tetsuaki" last="Arai">Tetsuaki Arai</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

LRRK2 expression in normal and pathologic human brain and in human cell lines

LRRK2 expression in normal and pathologic human brain and in human cell lines

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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